PROJECT

Patients with bad obstetric outcomes related to aPL (fulfilling full-blown Sydney criteria) may have a different clinical behavior than those with previous thrombotic history or than men suffering from APS. The rationale of this idea is based on the particular characteristics of maternal-fetal interface that may provoke different immunologic and inflammatory pathway activation and of its different long-term outcome, with a low prevalence of thrombotic events.

In the other way, women presenting clinical obstetric picture look alike those that fulfilled full-blown Sydney criteria (ie: two early miscarriages instead of three, abruption placenta), or women with accepted aPL-related obstetrical complications but without fulfilling the laboratory criteria according to Sydney recommendations (i.e: positive aPL test in two occasions but less than 12 weeks apart, low aPL titers, or positivity for non-standard aPL test), may also have incomplete forms, also named “possible” APS or “seronegative” APS. These cases would be better classified and treated if we had more detailed information and more cases included.

Due to these considerations, in the same way that other multicentre and international registers on different subtypes of APS have been started (ie: CAPS or Pediatric registry..) we considered that the creation of a European Multicentre Registry on OAPS (EROAPS) could be very useful in order to have a unique and homogeneous data bank where all of us would be able to send, consult or introduce data about patients. The accomplish with all items required (for discussion), might facilitate the following of the advised protocols. In the same way, this data base could be the core of multiple and necessary cooperating studies to cover several gaps that exist associated with aPL-related obstetric syndromes. In our Hospital, we have built a specific obstetric data base that could be discussed and modified in order to make it more useful and manageable. On the other hand, some questions have to be answered yet, and only through collaborative, prospective, well-designed studies may be resolved. In fact, the existence of common protocols and a centralized data base would make the task easier to be achieved.

The EUROAPS data base will be freely consulted on this web-site. It is expected that the periodical analysis of these data will let us increase our knowledge on this condition.

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